C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes …
CEB Couri, MCB Oliveira, ABPL Stracieri, DA Moraes… - Jama, 2009 - jamanetwork.com
Context In 2007, the effects of the autologous nonmyeloablative hematopoietic stem cell
transplantation (HSCT) in 15 patients with type 1 diabetes mellitus (DM) were reported. Most
patients became insulin free with normal levels of glycated hemoglobin A 1c (HbA 1c) during
a mean 18.8-month follow-up. To investigate if this effect was due to preservation of beta-cell
mass, continued monitoring was performed of C-peptide levels after stem cell
transplantation in the 15 original and 8 additional patients. Objective To determine C …
transplantation (HSCT) in 15 patients with type 1 diabetes mellitus (DM) were reported. Most
patients became insulin free with normal levels of glycated hemoglobin A 1c (HbA 1c) during
a mean 18.8-month follow-up. To investigate if this effect was due to preservation of beta-cell
mass, continued monitoring was performed of C-peptide levels after stem cell
transplantation in the 15 original and 8 additional patients. Objective To determine C …