[HTML][HTML] Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway
A Papapetropoulos, D Fulton, K Mahboubi… - Journal of Biological …, 2000 - ASBMB
A productive angiogenic response must couple to the survival machinery of endothelial cells
to preserve the integrity of newly formed vessels. Angiopoietin-1 (Ang-1) is an endothelium-
specific ligand essential for embryonic vascular stabilization, branching morphogenesis, and
post-natal angiogenesis, but its contribution to endothelial cell survival has not been
completely elucidated. Here we show that Ang-1 acting via the Tie 2 receptor induces
phosphorylation of the survival serine-threonine kinase, Akt (or protein kinase B). This is …
to preserve the integrity of newly formed vessels. Angiopoietin-1 (Ang-1) is an endothelium-
specific ligand essential for embryonic vascular stabilization, branching morphogenesis, and
post-natal angiogenesis, but its contribution to endothelial cell survival has not been
completely elucidated. Here we show that Ang-1 acting via the Tie 2 receptor induces
phosphorylation of the survival serine-threonine kinase, Akt (or protein kinase B). This is …