Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis

S David, A Mukherjee, CC Ghosh, M Yano… - Critical care …, 2012 - journals.lww.com
Objective: In sepsis, quiescent blood vessels become leaky and inflamed by mechanisms
that are incompletely understood. We hypothesized that angiopoietin-2, a partial antagonist
of the endothelium-stabilizing receptor Tie-2 secreted by endothelium, contributes to
adverse outcomes in this disease. Design: Laboratory and animal research. Settings:
Research laboratories and Emergency Department of Beth Israel Deaconess Medical
Center, Boston, MA. Subjects: Angiopoietin-2 heterozygous mice, emergency department …