[HTML][HTML] Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like …
U Fiedler, T Krissl, S Koidl, C Weiss, T Koblizek… - Journal of biological …, 2003 - ASBMB
Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) have been identified as ligands with
different effector functions of the vascular assembly and maturation-mediating receptor
tyrosine kinase Tie-2. To understand the molecular interactions of the angiopoietins with
their receptor, we have studied the binding of Ang-1 and Ang-2 to the Tie-2 receptor.
Enzyme-linked immunosorbent assay-based competition assays and co-
immunoprecipitation experiments analyzing the binding of Ang-1 and Ang-2 to truncation …
different effector functions of the vascular assembly and maturation-mediating receptor
tyrosine kinase Tie-2. To understand the molecular interactions of the angiopoietins with
their receptor, we have studied the binding of Ang-1 and Ang-2 to the Tie-2 receptor.
Enzyme-linked immunosorbent assay-based competition assays and co-
immunoprecipitation experiments analyzing the binding of Ang-1 and Ang-2 to truncation …