[HTML][HTML] Chemotactic properties of angiopoietin-1 and-2, ligands for the endothelial-specific receptor tyrosine kinase Tie2
B Witzenbichler, PC Maisonpierre, P Jones… - Journal of Biological …, 1998 - ASBMB
Angiopoietin-1 and its putative natural antagonist, angiopoietin-2, were recently isolated,
and the critical role of angiopoietin-1 in embryogenic angiogenesis was demonstrated by
targeted gene disruption. Specific biological effects of angiopoietin-1, however, have yet to
be defined. In this study we demonstrate that angiopoietin-1, but not angiopoietin-2, is
chemotactic for endothelial cells. In contrast, angiopoietin-1 as well as angiopoietin-2 exhibit
no proliferative effect on endothelial cells. Excess soluble Tie2, but not Tie1 receptor …
and the critical role of angiopoietin-1 in embryogenic angiogenesis was demonstrated by
targeted gene disruption. Specific biological effects of angiopoietin-1, however, have yet to
be defined. In this study we demonstrate that angiopoietin-1, but not angiopoietin-2, is
chemotactic for endothelial cells. In contrast, angiopoietin-1 as well as angiopoietin-2 exhibit
no proliferative effect on endothelial cells. Excess soluble Tie2, but not Tie1 receptor …