[HTML][HTML] Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2
MB Marron, H Singh, TA Tahir, J Kavumkal… - Journal of biological …, 2007 - ASBMB
Regulated ectodomain shedding followed by intramembrane proteolysis has recently been
recognized as important in cell signaling and for degradation of several type I
transmembrane proteins. The receptor-tyrosine kinase Tie1 is known to undergo
ectodomain cleavage generating a membrane-tethered endodomain. Here we show Tie1 is
a substrate for regulated intramembrane proteolysis. After Tie1 ectodomain cleavage the
newly formed 45-kDa endodomain undergoes additional proteolytic processing mediated by …
recognized as important in cell signaling and for degradation of several type I
transmembrane proteins. The receptor-tyrosine kinase Tie1 is known to undergo
ectodomain cleavage generating a membrane-tethered endodomain. Here we show Tie1 is
a substrate for regulated intramembrane proteolysis. After Tie1 ectodomain cleavage the
newly formed 45-kDa endodomain undergoes additional proteolytic processing mediated by …