The when and how of Src regulation

JA Cooper, B Howell - Cell, 1993 - cell.com
JA Cooper, B Howell
Cell, 1993cell.com
Retroviral Gag protein is capable of directing the assembly of virion particles independent of
other retroviral elements and plays an important role early in the infection of a cell. Using the
GAL4 two hybrid system, we screened a cDNA expression library and identified two host
proteins, cyclophillns (CyPs) A and B, which interact specifically with the human
immunodeficiency virus type 1 (HIV-1) Gag polyprotein Pr55 gag. Glutathione S-transferase-
CyP fusion proteins bind tightly to Pr55 gag in vitro, as well as to the HIV-1 capsid protein …
Retroviral Gag protein is capable of directing the assembly of virion particles independent of other retroviral elements and plays an important role early in the infection of a cell. Using the GAL4 two hybrid system, we screened a cDNA expression library and identified two host proteins, cyclophillns (CyPs) A and B, which interact specifically with the human immunodeficiency virus type 1 (HIV-1) Gag polyprotein Pr55 gag. Glutathione S-transferase-CyP fusion proteins bind tightly to Pr55 gag in vitro, as well as to the HIV-1 capsid protein p24.
cell.com