The formation of polyglutamine aggregates occupies a central role in the pathophysiology of
neurodegenerative diseases caused by expanded trinucleotide repeats encoding the amino
acid glutamine. This chapter describes sensitive histological methods for detection of tissue
sites that are capable of further recruitment of polyglutamine and for sites rich in
polyglutamine defined immunohistochemically. These methods have been found to be
applicable in a number of diseases and animal models of disease. Recruitment, which is a …