The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability

S Sharma, CM Helchowski, CE Canman - Mutation Research/Fundamental …, 2013 - Elsevier
Cancer cells display numerous abnormal characteristics which are initiated and maintained
by elevated mutation rates and genome instability. Chromosomal DNA is continuously
surveyed for the presence of damage or blocked replication forks by the DNA Damage
Response (DDR) network. The DDR is complex and includes activation of cell cycle
checkpoints, DNA repair, gene transcription, and induction of apoptosis. Duplicating a
damaged genome is associated with elevated risks to fork collapse and genome instability …