Gentamicin induced nitric oxide-related oxidative damages on vestibular afferents in the guinea pig
SH Hong, SK Park, YS Cho, HS Lee, KR Kim, MG Kim… - Hearing research, 2006 - Elsevier
Gentamicin is a well-known ototoxic aminoglycoside. However, the mechanism underlying
this ototoxicity remains unclear. One of the mechanisms which may be responsible for this
ototoxicity is excitotoxic damage to hair cells. The overstimulation of the N-methyl-d-
aspartate (NMDA) receptors increases the production of nitric oxide (NO), which induces
oxidative stress on hair cells. In order to determine the mechanism underlying this
excitotoxicity, we treated guinea pigs with gentamicin by placing gentamicin (0.5 mg) pellets …
this ototoxicity remains unclear. One of the mechanisms which may be responsible for this
ototoxicity is excitotoxic damage to hair cells. The overstimulation of the N-methyl-d-
aspartate (NMDA) receptors increases the production of nitric oxide (NO), which induces
oxidative stress on hair cells. In order to determine the mechanism underlying this
excitotoxicity, we treated guinea pigs with gentamicin by placing gentamicin (0.5 mg) pellets …