[HTML][HTML] The thiol-specific antioxidant enzyme prevents mitochondrial permeability transition: Evidence for the participation of reactive oxygen species in this …
Mitochondrial swelling and membrane protein thiol oxidation associated with mitochondrial
permeability transition induced by Ca 2+ and inorganic phosphate are inhibited in a dose-
dependent manner either by catalase, the thiol-specific antioxidant enzyme (TSA), a protein
recently demonstrated to present thiol peroxidase activity, or ebselen, a selenium-containing
heterocycle which also possesses thiol peroxidase activity. This inhibition of mitochondrial
permeability transition is due to the removal of mitochondrial-generated H 2 O 2 which can …
permeability transition induced by Ca 2+ and inorganic phosphate are inhibited in a dose-
dependent manner either by catalase, the thiol-specific antioxidant enzyme (TSA), a protein
recently demonstrated to present thiol peroxidase activity, or ebselen, a selenium-containing
heterocycle which also possesses thiol peroxidase activity. This inhibition of mitochondrial
permeability transition is due to the removal of mitochondrial-generated H 2 O 2 which can …