After almost seven decades in clinical use, aminoglycoside antibiotics still remain
indispensible drugs for acute infections and specific indications such as tuberculosis or the
containment of pseudomonas bacteria in patients with cystic fibrosis. The review will
describe the pathology and pathophysiology of aminoglycoside-induced auditory and
vestibular toxicity in humans and experimental animals and explore contemporary views of
the mechanisms of cell death. It will also outline the current state of protective therapy and …