Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation
J Yamada, S Yoshimura, H Yamakawa, M Sawada… - Neuroscience …, 2003 - Elsevier
The role of superoxide anion (O2−) in neuronal cell injury induced by reactive oxygen
species (ROS) was examined in PC12 cells using pyrogallol (1, 2, 3-benzenetrior), a donor
to release O2−. Pyrogallol induced PC12 cell death at concentrations, which evidently
increased intracellular O2−, as assessed by O2−-sensitive fluorescent precursor
hydroethidine (HEt). Caspase inhibitors, Z-VAD-FMK and Z-Asp-CH2-DCB, failed to protect
cells from injury caused by elevation of intracellular O2−, although these inhibitors had …
species (ROS) was examined in PC12 cells using pyrogallol (1, 2, 3-benzenetrior), a donor
to release O2−. Pyrogallol induced PC12 cell death at concentrations, which evidently
increased intracellular O2−, as assessed by O2−-sensitive fluorescent precursor
hydroethidine (HEt). Caspase inhibitors, Z-VAD-FMK and Z-Asp-CH2-DCB, failed to protect
cells from injury caused by elevation of intracellular O2−, although these inhibitors had …