Involvement of the mitochondrial permeability transition in gentamicin ototoxicity
N Dehne, U Rauen, H De Groot, J Lautermann - Hearing research, 2002 - Elsevier
Aminoglycosides may induce irreversible hearing loss in both animals and humans. In order
to study the nature and mechanisms underlying gentamicin-induced cell death in the inner
ear, the cochlear neurosensory epithelia were dissected from guinea pigs and incubated
with 0.5–10 mM gentamicin. Concentration-dependent loss of cell viability was detected by
the inability of damaged cells to exclude propidium iodide. Outer hair cells were most
sensitive towards gentamicin toxicity, followed by inner hair cells whereas Deiters and …
to study the nature and mechanisms underlying gentamicin-induced cell death in the inner
ear, the cochlear neurosensory epithelia were dissected from guinea pigs and incubated
with 0.5–10 mM gentamicin. Concentration-dependent loss of cell viability was detected by
the inability of damaged cells to exclude propidium iodide. Outer hair cells were most
sensitive towards gentamicin toxicity, followed by inner hair cells whereas Deiters and …