[HTML][HTML] Oxygen-bridged dinuclear ruthenium amine complex specifically inhibits Ca2+ uptake into mitochondria in vitroand in situ in single cardiac myocytes
MA Matlib, Z Zhou, S Knight, S Ahmed, KM Choi… - Journal of Biological …, 1998 - ASBMB
Ruthenium red is a well known inhibitor of Ca 2+ uptake into mitochondria in vitro. However,
its utility as an inhibitor of Ca 2+ uptake into mitochondria in vivo or in situ in intact cells is
limited because of its inhibitory effects on sarcoplasmic reticulum Ca 2+ release channel
and other cellular processes. We have synthesized a ruthenium derivative and found it to be
an oxygen-bridged dinuclear ruthenium amine complex. It has the same chemical structure
as Ru360 reported previously (Emerson, J., Clarke, MJ, Ying, WL., and Sanadi, DR (1993) J …
its utility as an inhibitor of Ca 2+ uptake into mitochondria in vivo or in situ in intact cells is
limited because of its inhibitory effects on sarcoplasmic reticulum Ca 2+ release channel
and other cellular processes. We have synthesized a ruthenium derivative and found it to be
an oxygen-bridged dinuclear ruthenium amine complex. It has the same chemical structure
as Ru360 reported previously (Emerson, J., Clarke, MJ, Ying, WL., and Sanadi, DR (1993) J …