Developmental differences in hair cell susceptibility to aminoglycoside-induced cell death
has been observed in multiple species. Increased sensitivity to aminoglycosides has been
temporally correlated with the onset of mechanotransduction-dependent activity. We have
used in vivo fluorescent vital dye markers to further investigate the determinants of
aminoglycoside induced hair cell death in the lateral line of zebrafish (Danio rerio). Labeling
hair cells of the lateral line in vivo with the dyes FM 1-43, To-Pro-3, and Yo-Pro-1 served as …