[HTML][HTML] The chromatin regulator Brpf1 regulates embryo development and cell proliferation
With hundreds of chromatin regulators identified in mammals, an emerging issue is how they
modulate biological and pathological processes. BRPF1 (bromodomain-and PHD finger-
containing protein 1) is a unique chromatin regulator possessing two PHD fingers, one
bromodomain and a PWWP domain for recognizing multiple histone modifications. In
addition, it binds to the acetyltransferases MOZ, MORF, and HBO1 (also known as KAT6A,
KAT6B, and KAT7, respectively) to promote complex formation, restrict substrate specificity …
modulate biological and pathological processes. BRPF1 (bromodomain-and PHD finger-
containing protein 1) is a unique chromatin regulator possessing two PHD fingers, one
bromodomain and a PWWP domain for recognizing multiple histone modifications. In
addition, it binds to the acetyltransferases MOZ, MORF, and HBO1 (also known as KAT6A,
KAT6B, and KAT7, respectively) to promote complex formation, restrict substrate specificity …