Structural emphysema does not correlate with lung compliance: lessons from the mouse smoking model
RF Foronjy, BA Mercer, MW Maxfield… - Experimental lung …, 2005 - Taylor & Francis
RF Foronjy, BA Mercer, MW Maxfield, CA Powell, J D'Armiento, Y Okada
Experimental lung research, 2005•Taylor & FrancisThe murine smoke-induced model produces histologic emphysema. The authors sought to
assess whether the structural emphysema that occurred correlated with the development of
compliance changes. The study exposed 2 strains of mice (CBA/J/J× C57BL/6J and A/J) to
chronic cigarette smoke. Lung compliance and morphometry were measured. The smoking
model generated significant emphysema in A/J mice in the absence of changes in
compliance, lung matrix, or apoptosis. Importantly, there was no correlation between the …
assess whether the structural emphysema that occurred correlated with the development of
compliance changes. The study exposed 2 strains of mice (CBA/J/J× C57BL/6J and A/J) to
chronic cigarette smoke. Lung compliance and morphometry were measured. The smoking
model generated significant emphysema in A/J mice in the absence of changes in
compliance, lung matrix, or apoptosis. Importantly, there was no correlation between the …
The murine smoke-induced model produces histologic emphysema. The authors sought to assess whether the structural emphysema that occurred correlated with the development of compliance changes. The study exposed 2 strains of mice (CBA/J/J × C57BL/6J and A/J) to chronic cigarette smoke. Lung compliance and morphometry were measured. The smoking model generated significant emphysema in A/J mice in the absence of changes in compliance, lung matrix, or apoptosis. Importantly, there was no correlation between the emphysema measured by lung morphometry and pulmonary compliance. This lack of correlation suggests that the mechanisms involved in anatomic emphysema may be distinct from those that cause the loss of elastic recoil.
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