Different expression patterns of Gli1–3 in mouse embryonic maxillofacial development

J Du, Z Fan, X Ma, Y Wu, S Liu, Y Gao, J Wang, Y Shen… - Acta histochemica, 2012 - Elsevier
The Sonic hedgehog (SHH) signaling pathway plays many key roles in the development of
Drosophila and vertebrate embryos, including regulating craniofacial development. The GLI
family of transcription factors (GLI1, 2, and 3) mediates the SHH morphogenetic signal by
regulating the expression of downstream target genes. Signaling aberrations seriously affect
vertebrate development. To better understand the regulation of GLI transcription factors, we
investigated the expression patterns of Gli1–3 during murine embryonic craniofacial …