[HTML][HTML] Enhancement of TWIK-related acid-sensitive potassium channel 3 (TASK3) two-pore domain potassium channel activity by tumor necrosis factor α
MF El Hachmane, KA Rees, EL Veale… - Journal of Biological …, 2014 - ASBMB
TASK3 two-pore domain potassium (K2P) channels are responsible for native leak K
channels in many cell types which regulate cell resting membrane potential and excitability.
In addition, TASK3 channels contribute to the regulation of cellular potassium homeostasis.
Because TASK3 channels are important for cell viability, having putative roles in both
neuronal apoptosis and oncogenesis, we sought to determine their behavior under
inflammatory conditions by investigating the effect of TNFα on TASK3 channel current …
channels in many cell types which regulate cell resting membrane potential and excitability.
In addition, TASK3 channels contribute to the regulation of cellular potassium homeostasis.
Because TASK3 channels are important for cell viability, having putative roles in both
neuronal apoptosis and oncogenesis, we sought to determine their behavior under
inflammatory conditions by investigating the effect of TNFα on TASK3 channel current …