[HTML][HTML] TNF-α decreases ABCA1 expression and attenuates HDL cholesterol efflux in the human intestinal cell line Caco-2
FJ Field, K Watt, SN Mathur - Journal of lipid research, 2010 - ASBMB
HDL cholesterol levels are decreased in Crohn's disease, a tumor necrosis factor-α (TNF-α)–
driven chronic inflammatory condition involving the gastrointestinal tract. ATP-binding
cassette transporter A1 (ABCA1), one of several liver X receptor (LXR) target genes, is a cell
surface transporter that mediates the rate-controlling step in HDL synthesis. The regulation
of ABCA1 and HDL cholesterol efflux by TNF-α was investigated in the human intestinal cell
line Caco-2. In response to cholesterol micelles or T0901317, an LXR nonsterol agonist …
driven chronic inflammatory condition involving the gastrointestinal tract. ATP-binding
cassette transporter A1 (ABCA1), one of several liver X receptor (LXR) target genes, is a cell
surface transporter that mediates the rate-controlling step in HDL synthesis. The regulation
of ABCA1 and HDL cholesterol efflux by TNF-α was investigated in the human intestinal cell
line Caco-2. In response to cholesterol micelles or T0901317, an LXR nonsterol agonist …