BRCA1 ubiquitylation of CtIP: Just the tIP of the iceberg?
LJ Barber, SJ Boulton - DNA repair, 2006 - Elsevier
Ubiquitylation is an important regulatory mechanism of many cellular processes. The breast
and ovarian cancer-specific tumour suppressor BRCA1 is well acknowledged to be a
RING/E3 ubiquitin ligase, however, identification of its physiological substrates has proved
elusive. Recently published data have shown that the BRCA1-interacting protein CtIP is in
fact ubiquitylated by BRCA1, and opens new avenues for the isolation of other substrate
proteins.
and ovarian cancer-specific tumour suppressor BRCA1 is well acknowledged to be a
RING/E3 ubiquitin ligase, however, identification of its physiological substrates has proved
elusive. Recently published data have shown that the BRCA1-interacting protein CtIP is in
fact ubiquitylated by BRCA1, and opens new avenues for the isolation of other substrate
proteins.