[HTML][HTML] Interaction of human immunodeficiency virus type 1 integrase with cellular nuclear import receptor importin 7 and its impact on viral replication
Z Ao, G Huang, H Yao, Z Xu, M Labine… - Journal of Biological …, 2007 - ASBMB
Similar to all other viruses, human immunodeficiency virus type 1 (HIV-1) depends heavily
on cellular factors for its successful replication. In this study we have investigated the
interaction of HIV-1 integrase (IN) with several host nuclear import factors using co-
immunoprecipitation assays. Our results indicate that IN interacts specifically with host
importin 7 (Imp7) in vivo, but does not interact with importin 8 (Imp8) or importin α (Rch1). In
contrast, another HIV-1 karyophilic protein MAp17, which is capable of binding Rch1, fails to …
on cellular factors for its successful replication. In this study we have investigated the
interaction of HIV-1 integrase (IN) with several host nuclear import factors using co-
immunoprecipitation assays. Our results indicate that IN interacts specifically with host
importin 7 (Imp7) in vivo, but does not interact with importin 8 (Imp8) or importin α (Rch1). In
contrast, another HIV-1 karyophilic protein MAp17, which is capable of binding Rch1, fails to …