Transplacental transfer and distribution of pravastatin
TN Nanovskaya, SL Patrikeeva, J Paul… - American journal of …, 2013 - Elsevier
Objective The objective of the study was to determine the bidirectional transfer of pravastatin
across the dually perfused term human placental lobule and its distribution between the
tissue and maternal and fetal circuits. Study Design The transfer of pravastatin was
determined in the maternal-to-fetal (n= 11) and fetal-to-maternal (n= 10) directions.
Pravastatin was coperfused with its [3 H]-isotope and the marker compound antipyrine (20
μg/mL) and its [14 C]-isotope. The concentration of pravastatin in the perfused tissue and the …
across the dually perfused term human placental lobule and its distribution between the
tissue and maternal and fetal circuits. Study Design The transfer of pravastatin was
determined in the maternal-to-fetal (n= 11) and fetal-to-maternal (n= 10) directions.
Pravastatin was coperfused with its [3 H]-isotope and the marker compound antipyrine (20
μg/mL) and its [14 C]-isotope. The concentration of pravastatin in the perfused tissue and the …