[HTML][HTML] Pregnancy outcome after first-trimester exposure to metformin: a meta-analysis
C Gilbert, M Valois, G Koren - Fertility and sterility, 2006 - Elsevier
OBJECTIVE: To conduct a systematic review and meta-analysis of pregnancy outcome after
metformin use for polycystic ovary syndrome (PCOS), because the efficacy of metformin has
been demonstrated in the treatment of infertility caused by PCOS, whereas the fetal safety of
metformin has received very little attention, and the few studies addressing this issue are
limited by small sample sizes. DESIGN: Meta-analytic review. SETTING: All pertinent studies
in MEDLINE and EMBASE from 1966 to September 2004. PATIENT (S): Women with PCOS …
metformin use for polycystic ovary syndrome (PCOS), because the efficacy of metformin has
been demonstrated in the treatment of infertility caused by PCOS, whereas the fetal safety of
metformin has received very little attention, and the few studies addressing this issue are
limited by small sample sizes. DESIGN: Meta-analytic review. SETTING: All pertinent studies
in MEDLINE and EMBASE from 1966 to September 2004. PATIENT (S): Women with PCOS …