[HTML][HTML] BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export
M Fabbro, JA Rodriguez, R Baer… - Journal of Biological …, 2002 - ASBMB
BRCA1 is a tumor suppressor with several important nuclear functions. BRCA1 has no
known cytoplasmic functions. We show here that the two previously identified nuclear
localization signals (NLSs) are insufficient for nuclear localization of BRCA1 due to the
opposing action of an NH 2-terminal nuclear export signal. In transfected breast cancer cells,
BRCA1 nuclear localization requires both the NLSs and NH 2-terminal RING domain region;
mutating either of these sequences shifts BRCA1 to the cytoplasm. The BRCA1 RING …
known cytoplasmic functions. We show here that the two previously identified nuclear
localization signals (NLSs) are insufficient for nuclear localization of BRCA1 due to the
opposing action of an NH 2-terminal nuclear export signal. In transfected breast cancer cells,
BRCA1 nuclear localization requires both the NLSs and NH 2-terminal RING domain region;
mutating either of these sequences shifts BRCA1 to the cytoplasm. The BRCA1 RING …