Quantitative measurement of F-actin accumulation at the NK cell immunological synapse
PP Banerjee, JS Orange - Journal of immunological methods, 2010 - Elsevier
NK cells are lymphocytes of the innate immune system that can kill target cells after
activation signal-induced directional secretion of lytic granule contents. This process
depends upon F-actin polymerization at the NK cell immunological synapse (NKIS), which is
the dynamic organization of molecules at the interface between the NK cell and target cell.
Although F-actin accumulation at the NKIS is easily visualized, the ability to quantify F-actin
at the NKIS is required to understand how F-actin reorganization and accumulation enable …
activation signal-induced directional secretion of lytic granule contents. This process
depends upon F-actin polymerization at the NK cell immunological synapse (NKIS), which is
the dynamic organization of molecules at the interface between the NK cell and target cell.
Although F-actin accumulation at the NKIS is easily visualized, the ability to quantify F-actin
at the NKIS is required to understand how F-actin reorganization and accumulation enable …