Repair and integrity of DNA ends at breaks, replication forks and telomeres are essential for
life; yet, paradoxically, these responses are, in many cases, controlled by a single protein
complex, Mre11–Rad50–Nbs1 (MRN). The MRN complex consists of dimers of each subunit
and this heterohexamer controls key sensing, signaling, regulation, and effector responses
to DNA double-strand breaks including ATM activation, homologous recombinational repair,
microhomology-mediated end joining and, in some organisms, non-homologous end …