Isozyme-specific effects of protein kinase C in pain modulation
Background Protein kinase C (PKC) is a family of serine/threonine kinases that contains
more than 10 isozymes. Evidence suggests that PKC may play important roles in pain
modulation, but the isozyme-specific effects of PKC on different aspects of pain modulation
are not fully understood. We hypothesize that different PKC isozymes play different roles in
different aspects of pain modulation. Methods The nociceptive behaviors of mice with
deletion of PKCα, β, γ, or δ in multiple pain models were compared with their respective wild …
more than 10 isozymes. Evidence suggests that PKC may play important roles in pain
modulation, but the isozyme-specific effects of PKC on different aspects of pain modulation
are not fully understood. We hypothesize that different PKC isozymes play different roles in
different aspects of pain modulation. Methods The nociceptive behaviors of mice with
deletion of PKCα, β, γ, or δ in multiple pain models were compared with their respective wild …