Transcriptional noise and the fidelity of initiation by RNA polymerase II
K Struhl - Nature structural & molecular biology, 2007 - nature.com
Nature structural & molecular biology, 2007•nature.com
Eukaryotes transcribe much of their genomes, but little is known about the fidelity of
transcriptional initiation by RNA polymerase II in vivo. I suggest that∼ 90% of Pol II initiation
events in yeast represent transcriptional noise, and that the specificity of initiation is
comparable to that of DNA-binding proteins and other biological processes. This
emphasizes the need to develop criteria that distinguish transcriptional noise from
transcription with a biological function.
transcriptional initiation by RNA polymerase II in vivo. I suggest that∼ 90% of Pol II initiation
events in yeast represent transcriptional noise, and that the specificity of initiation is
comparable to that of DNA-binding proteins and other biological processes. This
emphasizes the need to develop criteria that distinguish transcriptional noise from
transcription with a biological function.
Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo. I suggest that ∼90% of Pol II initiation events in yeast represent transcriptional noise, and that the specificity of initiation is comparable to that of DNA-binding proteins and other biological processes. This emphasizes the need to develop criteria that distinguish transcriptional noise from transcription with a biological function.
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