Comparison of the Vβ repertoire in peripheral blood and in lymph nodes of HIV-infected subjects reveals skewed usage predominantly in CD8+ T cells
M Carbonari, M Cibati, AM Pesce, L Dell'anna… - Clinical immunology and …, 1996 - Elsevier
Perturbations of the repertoire of variable-β (Vβ) regions of the T cell receptor have been
observed in patients infected by HIV and have been attributed to stimulation by viral
antigens or superantigens. We further sought for traces of HIV-induced perturbations by
comparing Vβ repertoire in peripheral blood and in lymphoid tissues of six infected patients.
Vβ expression was studied with a panel of 17 anti-Vβ antibodies covering about 50% of the
entire repertoire. We observed major divergences between lymph nodes and peripheral …
observed in patients infected by HIV and have been attributed to stimulation by viral
antigens or superantigens. We further sought for traces of HIV-induced perturbations by
comparing Vβ repertoire in peripheral blood and in lymphoid tissues of six infected patients.
Vβ expression was studied with a panel of 17 anti-Vβ antibodies covering about 50% of the
entire repertoire. We observed major divergences between lymph nodes and peripheral …