[HTML][HTML] Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model
T Wang, EB Ahmed, L Chen, J Xu, J Tao… - American Journal of …, 2010 - Elsevier
Infections and TLR signals at the time of transplantation have been shown to prevent the
induction of tolerance, but their effect on allografts after tolerance has been established is
unclear. We here report that infection with Listeria monocytogenes precipitated the loss of
tolerance and the MyD88‐and T cell‐dependent rejection of accepted cardiac allografts in
mice. This loss of tolerance was associated with increases in the numbers of graft‐infiltrating
macrophages and dendritic cells, as well as CD4+ FoxP3− and CD8+ T cells. Rejection was …
induction of tolerance, but their effect on allografts after tolerance has been established is
unclear. We here report that infection with Listeria monocytogenes precipitated the loss of
tolerance and the MyD88‐and T cell‐dependent rejection of accepted cardiac allografts in
mice. This loss of tolerance was associated with increases in the numbers of graft‐infiltrating
macrophages and dendritic cells, as well as CD4+ FoxP3− and CD8+ T cells. Rejection was …