Forced expression of selected transcription factors can transform somatic cells into
embryonic stem cell (ESC)-like cells, termed induced pluripotent stem cells (iPSCs). There is
no consensus regarding the preferred tissue from which to harvest donor cells for
reprogramming into iPSCs, and some donor cell types may be more prone than others to
accumulation of epigenetic imprints and somatic cell mutations. Here, we present a simple,
reproducible, noninvasive method for generating human iPSCs from renal tubular cells …