Thymic stromal lymphopoietin links keratinocytes and dendritic cell–derived IL-23 in patients with psoriasis
E Volpe, L Pattarini, C Martinez-Cingolani… - Journal of Allergy and …, 2014 - Elsevier
Background Thymic stromal lymphopoietin (TSLP) is a major proallergic cytokine that
promotes TH 2 responses through dendritic cell (DC) activation. Whether it also plays a role
in human autoimmune inflammation and associated pathways is not known. Objective In this
study we investigated the potential role of several epithelium-derived factors, including
TSLP, in inducing IL-23 production by human DCs. We further dissected the role of TSLP in
patients with psoriasis, an IL-23–associated skin autoimmune disease. Methods The study …
promotes TH 2 responses through dendritic cell (DC) activation. Whether it also plays a role
in human autoimmune inflammation and associated pathways is not known. Objective In this
study we investigated the potential role of several epithelium-derived factors, including
TSLP, in inducing IL-23 production by human DCs. We further dissected the role of TSLP in
patients with psoriasis, an IL-23–associated skin autoimmune disease. Methods The study …