A medical treatment for diacetylmorphine (heroin) addiction: a clinical trial with methadone hydrochloride

VP Dole, M Nyswander - Jama, 1965 - jamanetwork.com
A group of 22 patients, previously addicted to diacetylmorphine (heroin), have been
stabilized with oral methadone hydrochloride. This medication appears to have two useful
effects:(1) relief of narcotic hunger, and (2) induction of sufficient tolerance to block the
euphoric effect of an average illegal dose of diacetylmorphine. With this medication, and a
comprehensive program of rehabilitation, patients have shown marked improvement; they
have returned to school, obtained jobs, and have become reconciled with their families …