AT1 receptor heterodimers and angiotensin II responsiveness in preeclampsia
U Quitterer, H Lother, S Abdalla - Seminars in nephrology, 2004 - Elsevier
Preeclampsia is a pregnancy-specific hypertensive disorder with unknown etiology, which
affects 5% to 10% of all pregnancies. Increased sensitivity to the vasoconstrictor angiotensin
II is a common feature of preeclampsia, although underlying mechanisms are barely
understood. Recent data reveal a potential mechanism for the increased angiotensin II
responsiveness in preeclampsia: increased levels of heterodimers between the vasopressor
receptor AT1 and the vasodepressor receptor B2. The receptor heterodimers display …
affects 5% to 10% of all pregnancies. Increased sensitivity to the vasoconstrictor angiotensin
II is a common feature of preeclampsia, although underlying mechanisms are barely
understood. Recent data reveal a potential mechanism for the increased angiotensin II
responsiveness in preeclampsia: increased levels of heterodimers between the vasopressor
receptor AT1 and the vasodepressor receptor B2. The receptor heterodimers display …