[HTML][HTML] Estrogen receptor α signaling regulates breast tumor-initiating cells by down-regulating miR-140 which targets the transcription factor SOX2
Y Zhang, G Eades, Y Yao, Q Li, Q Zhou - Journal of Biological Chemistry, 2012 - ASBMB
Several reports have indicated that miR-140, a possible tumor suppressor microRNA (miR),
is down-regulated in breast tumors compared with normal breast tissues. However, the role
of miR-140 in breast tumorigenesis is unclear. We initiated studies that examined estrogen
receptor α (ERα) signaling in the tissue-specific regulation of miR-140 in breast cancer. We
found that estrogen stimulation of ERα-positive breast cancer cells resulted in decreased
miR-140 expression. We performed promoter analyses and examined predicted ERα …
is down-regulated in breast tumors compared with normal breast tissues. However, the role
of miR-140 in breast tumorigenesis is unclear. We initiated studies that examined estrogen
receptor α (ERα) signaling in the tissue-specific regulation of miR-140 in breast cancer. We
found that estrogen stimulation of ERα-positive breast cancer cells resulted in decreased
miR-140 expression. We performed promoter analyses and examined predicted ERα …