Allergic inflammation: role of cytokines with special emphasis on IL-4
A Saggini, G Maccauro, D Tripodi… - International …, 2011 - journals.sagepub.com
A Saggini, G Maccauro, D Tripodi, MA De Lutiis, F Conti, P Felaco, M Fulcheri, R Galzio…
International Journal of Immunopathology and Pharmacology, 2011•journals.sagepub.comThis review examines recent articles on the relationship of cytokines to allergy and
inflammation with particular emphasis on interleukin (IL)-4. The objective of this article is
therefore to review published studies to identify cytokines consistently involved in allergic
inflammation. Proinflammatory cytokines, including IL-4, IL-5, IL-13 and GM-CSF along with
TNF-alpha play a role in allergen-induced airway leukocyte recruitment and these cytokines
can be generated by T mast cells and other cells. In addition, IL-9, IL-25, IL-33, IL-17, IL-27 …
inflammation with particular emphasis on interleukin (IL)-4. The objective of this article is
therefore to review published studies to identify cytokines consistently involved in allergic
inflammation. Proinflammatory cytokines, including IL-4, IL-5, IL-13 and GM-CSF along with
TNF-alpha play a role in allergen-induced airway leukocyte recruitment and these cytokines
can be generated by T mast cells and other cells. In addition, IL-9, IL-25, IL-33, IL-17, IL-27 …
This review examines recent articles on the relationship of cytokines to allergy and inflammation with particular emphasis on interleukin (IL)-4. The objective of this article is therefore to review published studies to identify cytokines consistently involved in allergic inflammation. Proinflammatory cytokines, including IL-4, IL-5, IL-13 and GM-CSF along with TNF-alpha play a role in allergen-induced airway leukocyte recruitment and these cytokines can be generated by T mast cells and other cells. In addition, IL-9, IL-25, IL-33, IL-17, IL-27 and IFN-γ are deeply involved in the regulation of asthma. Blocking the effect of these proinflammatory cytokines might provide new therapeutic approaches for the control of allergy and inflammation.
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