Activation of ERK1/2 MAP kinase pathway induces tight junction disruption in human corneal epithelial cells
Y Wang, J Zhang, X Yi, XY Fu-Shin - Experimental eye research, 2004 - Elsevier
Activation of protein kinase C (PKC) by exposure of cultured human corneal epithelial cells
to phorbol 12-myristate 13-acetate (PMA) resulted in an increase in paracellular
permeability as evidenced by a decrease in transepithelial electrical resistance (TER). A
change in the membrane distribution of the tight junction protein ZO-1 was also observed in
the PMA-treated cells. In contrast, when the cells were treated with PMA in the presence of
PD98059, a specific inhibitor of mitogen-activated protein kinase (MAPK) kinase, all barrier …
to phorbol 12-myristate 13-acetate (PMA) resulted in an increase in paracellular
permeability as evidenced by a decrease in transepithelial electrical resistance (TER). A
change in the membrane distribution of the tight junction protein ZO-1 was also observed in
the PMA-treated cells. In contrast, when the cells were treated with PMA in the presence of
PD98059, a specific inhibitor of mitogen-activated protein kinase (MAPK) kinase, all barrier …