[HTML][HTML] Genetic and molecular basis of inflammasome-mediated disease
HM Hoffman, SD Brydges - Journal of Biological Chemistry, 2011 - ASBMB
The central function of IL-1ß in fever regulation was recognized with its discovery 30 years
ago (1). It was an attractive candidate as a master regulator in the pathogenesis of the
hereditary fever syndromes; however, definitive proof was elusive. The mechanisms
enabling maturation and release of active IL-1ß are complex, and it was difficult to detect the
cytokine in patient serum. Validation of its central role in these rare autoinflammatory
conditions was achieved in the last decade with the convergence of three major …
ago (1). It was an attractive candidate as a master regulator in the pathogenesis of the
hereditary fever syndromes; however, definitive proof was elusive. The mechanisms
enabling maturation and release of active IL-1ß are complex, and it was difficult to detect the
cytokine in patient serum. Validation of its central role in these rare autoinflammatory
conditions was achieved in the last decade with the convergence of three major …