Intestinal neuronal dysplasia-like pathology in Ncx/Hox11L. 1 gene-deficient mice
A Yamataka, M Hatano, H Kobayashi, K Wang… - Journal of pediatric …, 2001 - Elsevier
Background/Purpose: Ncx/Hox11L. 1-deficient (Ncx-/-) mice specifically created by the
authors had mega-ileo-ceco-colon (mega-ICC) with a caliber change in the proximal colon.
The authors studied the nerve distribution in the bowel of these Ncx-/-mice to determine the
cause of their bowel dysmotility. Methods: Four-week-old Ncx-/-mice (n= 10; 5 with mega-
ICC, 5 without mega-ICC) were killed and the bowel harvested. Half of each specimen was
snap frozen for AchE and NADPH-diaphorase histochemistry, and the other half were fixed …
authors had mega-ileo-ceco-colon (mega-ICC) with a caliber change in the proximal colon.
The authors studied the nerve distribution in the bowel of these Ncx-/-mice to determine the
cause of their bowel dysmotility. Methods: Four-week-old Ncx-/-mice (n= 10; 5 with mega-
ICC, 5 without mega-ICC) were killed and the bowel harvested. Half of each specimen was
snap frozen for AchE and NADPH-diaphorase histochemistry, and the other half were fixed …