Acute kidney injury: an increasing global concern

NH Lameire, A Bagga, D Cruz, J De Maeseneer… - The Lancet, 2013 - thelancet.com
NH Lameire, A Bagga, D Cruz, J De Maeseneer, Z Endre, JA Kellum, KD Liu, RL Mehta
The Lancet, 2013thelancet.com
Despite an increasing incidence of acute kidney injury in both high-income and low-income
countries and growing insight into the causes and mechanisms of disease, few preventive
and therapeutic options exist. Even small acute changes in kidney function can result in
short-term and long-term complications, including chronic kidney disease, end-stage renal
disease, and death. Presence of more than one comorbidity results in high severity of illness
scores in all medical settings. Development or progression of chronic kidney disease after …
Summary
Despite an increasing incidence of acute kidney injury in both high-income and low-income countries and growing insight into the causes and mechanisms of disease, few preventive and therapeutic options exist. Even small acute changes in kidney function can result in short-term and long-term complications, including chronic kidney disease, end-stage renal disease, and death. Presence of more than one comorbidity results in high severity of illness scores in all medical settings. Development or progression of chronic kidney disease after one or more episode of acute kidney injury could have striking socioeconomic and public health outcomes for all countries. Concerted international action encompassing many medical disciplines is needed to aid early recognition and management of acute kidney injury.
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