Factors regulating growth hormone secretion in humans

N Goldenberg, A Barkan - Endocrinology and Metabolism …, 2007 - endo.theclinics.com
Growth hormone (GH) secretion is pulsatile in nature in all species. The periodic pattern of
GH release plays an important role in transmitting the GH message in a tissue-specific
manner. For example, only pulsatile GH can normalize muscle and cartilage insulin-like
growth factor (IGF)-1 mRNA levels [1] and only the continuous component of GH's secretory
profile induces hepatic mRNAs for certain cytochrome P-450 enzymes [2]. The question of
what regulates the pulsatile GH secretion pattern is an issue of not only theoretical interest …