In vivo visualisation of murine corneal nerve fibre regeneration in response to ciliary neurotrophic factor
M Reichard, M Hovakimyan, RF Guthoff… - Experimental Eye …, 2014 - Elsevier
The aim of this study was to examine the murine subbasal nerve fibre plexus (SNP)
regeneration altered by surgical dissection. Investigations in the mouse model addressed
the regeneration capabilities of the SNP, and the influence of local ciliary neurotrophic factor
(CNTF) application on the regeneration process. In preliminary experiments, the healthy
mouse cornea was monitored using in vivo confocal laser-scanning microscopy (CLSM)
from the age of 8–52 weeks, to reveal and rule out the age-dependent changes in SNP …
regeneration altered by surgical dissection. Investigations in the mouse model addressed
the regeneration capabilities of the SNP, and the influence of local ciliary neurotrophic factor
(CNTF) application on the regeneration process. In preliminary experiments, the healthy
mouse cornea was monitored using in vivo confocal laser-scanning microscopy (CLSM)
from the age of 8–52 weeks, to reveal and rule out the age-dependent changes in SNP …