Humanized mice in translational biomedical research
LD Shultz, F Ishikawa, DL Greiner - Nature Reviews Immunology, 2007 - nature.com
LD Shultz, F Ishikawa, DL Greiner
Nature Reviews Immunology, 2007•nature.comThe culmination of decades of research on humanized mice is leading to advances in our
understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity,
infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss
the development of these new generations of humanized mice, how they will facilitate
translational research in several biomedical disciplines and approaches to overcome the
remaining limitations of these models.
understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity,
infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss
the development of these new generations of humanized mice, how they will facilitate
translational research in several biomedical disciplines and approaches to overcome the
remaining limitations of these models.
Abstract
The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.
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