Sterile inflammation: sensing and reacting to damage

GY Chen, G Nuņez - Nature Reviews Immunology, 2010 - nature.com
Nature Reviews Immunology, 2010nature.com
Over the past several decades, much has been revealed about the nature of the host innate
immune response to microorganisms, with the identification of pattern recognition receptors
(PRRs) and pathogen-associated molecular patterns, which are the conserved microbial
motifs sensed by these receptors. It is now apparent that these same PRRs can also be
activated by non-microbial signals, many of which are considered as damage-associated
molecular patterns. The sterile inflammation that ensues either resolves the initial insult or …
Abstract
Over the past several decades, much has been revealed about the nature of the host innate immune response to microorganisms, with the identification of pattern recognition receptors (PRRs) and pathogen-associated molecular patterns, which are the conserved microbial motifs sensed by these receptors. It is now apparent that these same PRRs can also be activated by non-microbial signals, many of which are considered as damage-associated molecular patterns. The sterile inflammation that ensues either resolves the initial insult or leads to disease. Here, we review the triggers and receptor pathways that result in sterile inflammation and its impact on human health.
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