[HTML][HTML] Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARγ and C/EBPα
AK El-Jack, JK Hamm, PF Pilch, SR Farmer - Journal of Biological …, 1999 - ASBMB
Adipocyte differentiation is regulated by at least two major transcription factors,
CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor
γ (PPARγ). Expression of PPARγ in fibroblasts converts them to fat-laden cells with an
adipocyte-like morphology. Here, we investigate the ability of PPARγ to confer insulin-
sensitive glucose transport to a variety of murine fibroblast cell lines. When cultured in the
presence of a PPARγ ligand, Swiss-3T3 and BALB/c-3T3 cells ectopically expressing …
CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor
γ (PPARγ). Expression of PPARγ in fibroblasts converts them to fat-laden cells with an
adipocyte-like morphology. Here, we investigate the ability of PPARγ to confer insulin-
sensitive glucose transport to a variety of murine fibroblast cell lines. When cultured in the
presence of a PPARγ ligand, Swiss-3T3 and BALB/c-3T3 cells ectopically expressing …