Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent
M Bianchi, MJ Niemiec, U Siler, CF Urban… - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: Aspergillus spp infection is a potentially lethal disease in patients with
neutropenia or impaired neutrophil function. We showed previously that Aspergillus hyphae,
too large for neutrophil phagocytosis, are inhibited by reactive oxygen species-dependent
neutrophil extracellular trap (NET) formation. This process is defective in chronic
granulomatous disease (CGD) because of impaired phagocyte nicotinamide adenine
dinucleotide phosphate (NADPH) oxidase function. OBJECTIVE: To determine the …
neutropenia or impaired neutrophil function. We showed previously that Aspergillus hyphae,
too large for neutrophil phagocytosis, are inhibited by reactive oxygen species-dependent
neutrophil extracellular trap (NET) formation. This process is defective in chronic
granulomatous disease (CGD) because of impaired phagocyte nicotinamide adenine
dinucleotide phosphate (NADPH) oxidase function. OBJECTIVE: To determine the …