Serum exosomal P-glycoprotein is a potential marker to diagnose docetaxel resistance and select a taxoid for patients with prostate cancer
T Kato, K Mizutani, K Kameyama, K Kawakami… - … Oncology: Seminars and …, 2015 - Elsevier
Objectives Docetaxel is used as the first-line chemotherapy for castration-resistant prostate
cancer (CRPC), but docetaxel resistance occurs in part owing to induction of P-glycoprotein
(P-gp) encoded by multidrug resistance protein 1 (MDR1) gene. A recently developed
taxane—cabazitaxel—has poor affinity for P-gp and is thereby effective in docetaxel-
resistant CRPC. It has been recently demonstrated that exosomes in the body fluids could
serve as a diagnostic marker because they contain proteins and RNAs specific to the cells …
cancer (CRPC), but docetaxel resistance occurs in part owing to induction of P-glycoprotein
(P-gp) encoded by multidrug resistance protein 1 (MDR1) gene. A recently developed
taxane—cabazitaxel—has poor affinity for P-gp and is thereby effective in docetaxel-
resistant CRPC. It has been recently demonstrated that exosomes in the body fluids could
serve as a diagnostic marker because they contain proteins and RNAs specific to the cells …