[HTML][HTML] Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes
E Hosseini-Beheshti, S Pham, H Adomat, N Li… - Molecular & Cellular …, 2012 - ASBMB
Prostate cancer is the leading type of cancer diagnosed in men. In 2010,∼ 217,730 new
cases of prostate cancer were reported in the United States. Prompt diagnosis of the disease
can substantially improve its clinical outcome. Improving capability for early detection, as
well as developing new therapeutic targets in advanced disease are research priorities that
will ultimately lead to better patient survival. Eukaryotic cells secrete proteins via distinct
regulated mechanisms which are either ER/Golgi dependent or microvesicle mediated. The …
cases of prostate cancer were reported in the United States. Prompt diagnosis of the disease
can substantially improve its clinical outcome. Improving capability for early detection, as
well as developing new therapeutic targets in advanced disease are research priorities that
will ultimately lead to better patient survival. Eukaryotic cells secrete proteins via distinct
regulated mechanisms which are either ER/Golgi dependent or microvesicle mediated. The …